Fe-dependent cellular alterations of oxidative balance in aquatic organisms. Could be ferroptosis involved?

The purpose of this review is to briefly summarize the central role iron (Fe) in terms cellular alterations oxidative/protective balance with special emphasis on its possible involvement ferroptosis-dependent disruption aquatic organisms. In ferroptotic cells or tissues, intracellular Fe level increases; meanwhile treatment chelators limits ferroptosis. Eukaryotic algae can assimilate from environment through several mechanisms, and animals incorporate dissolved bound both inorganic particles organic matter. lipid peroxidation mediating ferroptosis was demonstrated some where low high concentrations could induce oxidative stress programmed cell death. Aquatic have levels polyunsaturated fatty acids numerous studies analyzed effects lipidic fraction which be related reaction regulated antioxidant defense system, combination protein degradation structure, metabolism, gene transcription. Early depletion non-enzymatic antioxidants like reduced glutathione (GSH) animals, reduction GSH ascorbate photosynthetic organisms, are characteristic features Therefore, prevented if chelators, certain antioxidants, specifically regulating genes activated. Thus, global scenario for as a toxic component biological systems seems even more complicated than it previously understood. Much research subject needed improve life span survival organisms after exposure natural anthropogenic adverse conditions.